Irradiación gamma aplicada a la síntesis de nanopartículas de selenio y su influencia en las propiedades fisicoquímicas.
DOI:
https://doi.org/10.15392/2319-0612.2026.3078Palabras clave:
Irradiación gamma, Química verde, Caracterización de nanopartículas, Nanopartículas de selenioResumen
El selenio, un micronutriente esencial en pequeñas cantidades, presenta numerosos efectos beneficiosos en organismos como humanos, plantas y bacterias. Sin embargo, la relación entre el selenio y los organismos vivos es compleja debido a su estrecho rango de acción, que puede variar de beneficioso a perjudicial dependiendo de la concentración. Las nanopartículas de selenio (SeNPs) muestran un gran potencial debido a su reconocida biocompatibilidad, biodisponibilidad y baja toxicidad. No obstante, antes de considerar cualquier aplicación potencial, los parámetros fisicoquímicos de las SeNPs — como tamaño, forma, composición, estado de agregación y carga superficial — deben caracterizarse cuidadosamente, ya que la metodología de síntesis puede influir en su toxicidad. En el presente estudio utilizamos un método radiolítico, empleando radiación de ⁶⁰Co, para sintetizar SeNPs y posteriormente evaluamos detalladamente sus parámetros fisicoquímicos.
Descargas
Referencias
[1] M. G. LINES. Nanomaterials for practical functional uses, Journal of Alloys and Compounds, Sydney, v. 449, p. 242–245, 2008. DOI: https://doi.org/10.1016/j.jallcom.2006.02.082
[2] R. SINGH.; H. S. NALMA. Medical applications of nanoparticles in biological imaging, cell labeling, antimicrobial agents, and anticancer nanodrugs. Journal of Biomedical Nanotechnology, Stevenson Ranch, v. 7, n. 4, p. 489–503, 2011. DOI: https://doi.org/10.1166/jbn.2011.1324
[3] I. A. H. KHALIL.; I. A. ARIDA.; M. AHMED. Introductory Chapter: Overview on nanomedicine market. In: KHALIL. I. A. H. (Ed.). Current and Future Aspects of Nanomedicine. IntechOpen, 2020. ISBN 978-1-78985-870-9.
[4] N. BISHT.; P. PHALSWAL.; P. K. KHANNA. Selenium nanoparticles: A review on synthesis and biomedical applications. Materials Advance, Pune, v. 3, n. 3, p. 1415-1431, 2022. DOI: https://doi.org/10.1039/D1MA00639H
[5] R. RIDOLFO.; S. TAVAKOLI.; V. JUNNUTHULA.; D. S. WILLIAMS.; A. URTTI.; J. C. M. VAN HEST. Exploring the impact of morphology on the properties of biodegradable nanoparticles and their diffusion in complex biological medium. Biomacromolecules, Eindhoven, v. 22, n. 1, p. 126–133, 2021. DOI: https://doi.org/10.1021/acs.biomac.0c00726
[6] A. ABEDINI.; A. R. DAUD.; M. AZMI.; A. HAMID.; N. K. OTHMAN.; E. SAION. A review on radiation-induced nucleation and growth of colloidal metallic nanoparticles. Nanoscale Research Letters, Bangi, v. 8, p. 474, 2013. DOI: https://doi.org/10.1186/1556-276X-8-474
[7] S., LE CAER. Water radiolysis: Influence of oxide surfaces on H2 production under ionizing radiation. Water, Gif-sur-Yvette, v. 3, n. 1, p. 235–253, 2011. DOI: https://doi.org/10.3390/w3010235
[8] F. M. MOSALLAM.; G. S. EL-SAYYAD.; R. M. FATHY.; A. I. EL-BATAL. Biomoleculesmediated synthesis of selenium nanoparticles using Aspergillus oryzae fermented Lupin extract and gamma radiation for hindering the growth of some multidrug-resistant bacteria and pathogenic fungi. Microbial Pathogenesis, Cairo, v. 122, p. 108-116, 2018. DOI: https://doi.org/10.1016/j.micpath.2018.06.013
[9] J. BELLONI.; J. L. MARIGNIER.; M. MOSTAFAVI, Mechanisms of metal nanoparticles nucleation and growth studied by radiolysis. Radiation Physics and Chemistry, Orsay, v. 169. p. 107952, 2020. DOI: https://doi.org/10.1016/j.radphyschem.2018.08.001
[10] A. ABEDINI.; A. R. DAUD.; M. A. A. HAMID.; N. K. OTHMAN. Radiolytic formation of Fe3O4 nanoparticles: Influence of radiation dose on structure and magnetic properties. PLoS ONE, Bangi, v. 9, n. 3, 2014. DOI: https://doi.org/10.1371/journal.pone.0090055
[11] L. M. ALREHAILY. ; J. M. JOSEPH. ; M. C. BIESINGER.; D. A. GUZONAS. ; J. C. WREN. Gamma-radiolysis-assisted cobalt oxide nanoparticle formation. Physical Chemistry Chemical Physics, Ontario, v. 15, n. 3, p. 1014–1024, 2013. DOI: https://doi.org/10.1039/C2CP43094K
[12] P. ANASTAS. ; N. EGHBALI. Green Chemistry: Principles and Practice. Chemical Society Reviews, New Haven, v. 39, n. 1, p. 301–312, 2010. DOI: https://doi.org/10.1039/B918763B
[13] D. C. CLIFFORD. ; C. E. CASTANO. ; J. ROJAS. Supported transition metal nanomaterials: Nanocomposites synthesized by ionizing radiation. Radiation Physics and Chemistry, Virginia, v. 132, p. 52–64, 2017. DOI: https://doi.org/10.1016/j.radphyschem.2016.12.001
[14] J. A. LAVERNE. Track Effects of Heavy Ions in Liquid Water. Radiation Research, Indiana, v. 153, p. 487–496, 2000. DOI: https://doi.org/10.1667/0033-7587(2000)153[0487:TEOHII]2.0.CO;2
[15] G. ROS. ; G. SÁEZ-CANO. ; G. A. MEDINA-TANCO. ; A. D. SUPANITSKY. On the design of experiments based on plastic scintillators using GEANT4 simulations. Radiation Physics and Chemistry, Alcalá de Henares, v. 153, p. 140–151, 2018. DOI: https://doi.org/10.1016/j.radphyschem.2018.09.021
[16] M. A. Ruiz-Fresneda, L. C. Staicu, G. Lazuén-López, M. L. Merroun, Allotropy of selenium nanoparticles: Colourful transition, synthesis, and biotechnological applications. Microbial Biotechnology, Granada, v. 16, n. 5, p. 877–892, 2023. DOI: https://doi.org/10.1111/1751-7915.14209
[17] C. DWIVEDI. ; C. P. SHAH. ; K. SINGH. ; M. KUMAR. ; P. N. BAJAJ. An organic acid- induced synthesis and characterization of selenium nanoparticles. Journal of Nanotechnology, Mumbai, 2011. DOI: https://doi.org/10.1155/2011/651971
[18] A. G. PEREIRA. ; L. G. L. GEROLIS. ; L. S. GONÇALVES. ; L. M. C. MOREIRA. ; P. L. GASTELOIS. ; M. J. NEVES. Radiolytic synthesis and characterization of selenium nanoparticles: comparative biosafety evaluation with selenite and ionizing radiation. World Journal Microbiology Biotechnology, v. 38 n. 2, 2022. DOI: https://doi.org/10.1007/s11274-021-03218-9
[19] A. A. A. TARMIZI. ; N. N. N. RAMLI. ; S. H. ADAM.; M. A. MUTALIB.; M. H. MOKHTAR. ; S. G. H. TANG. Phytofabrication of selenium nanoparticles with Moringa oleifera (MO-SeNPs) and exploring its antioxidant and antidiabetic potential. Molecules, Shah Alam, v. 28, n. 14, 2023. DOI: https://doi.org/10.3390/molecules28145322
[20] B. H. AMIN.; H.Y. AHMED. ; E. M. EL GAZZAR. ; M. M. M. BADAWY. Enhancement the mycosynthesis of selenium nanoparticles by using gamma radiation. Dose- Response, Cairo, v. 19, n. 4, 2021. DOI: https://doi.org/10.1177/15593258211059323
[21] E. SAION. ; E. GHARIBSHAHI. ; K. NAGHAVI. Size-controlled and optical properties of monodispersed silver nanoparticles synthesized by the radiolytic reduction method. International Journal of Molecular, Selangor, v. 14, n. 4, p. 7880–7896, 2013. DOI: https://doi.org/10.3390/ijms14047880
[22] BELLONI, J.; MOSTAFAVI, M.; REMITA, H.; MARIGNIER, J. L.; DELCOURT, M. O. Radiation-induced synthesis of mono- and multi-metallic clusters and nanocolloids. New Journal of Chemistry, Cambridge, v. 22, n. 11, p. 1239–1255, 1998. DOI: https://doi.org/10.1039/a801445k
[23] FINNEY, E. E.; FINKE, R. G. Nanocluster nucleation and growth kinetic and mechanistic studies: A review emphasizing transition-metal nanoclusters. Journal of Colloid and Interface Science, Orlando, v. 317, n. 2, p. 351–374, 2008. DOI: https://doi.org/10.1016/j.jcis.2007.05.092
[24] NAGHAVI, K.; SAION, E.; REZAEE, K.; YUNUS, W. M. M. Influence of dose on particle size of colloidal silver nanoparticles synthesized by gamma radiation. Radiation Physics and Chemistry, Oxford, v. 79, n. 12, p. 1203–1208, 2010.
[25] SERRANO-LOTINA, A.; PORTELA, R.; BAEZA, P.; ALCOLEA-RODRÍGUEZ, V.; VILLARROEL, M.; ÁVILA, P. Zeta potential as a tool for functional materials development. Catalysis Today, Amsterdam, v. 423, p. 113862, 2023. DOI: https://doi.org/10.1016/j.cattod.2022.08.004
[26] MALVERN PANALYTICAL. Polydispersity: what does it mean for DLS and chromatography? Disponível em: https://www.malvernpanalytical.com/en/learn/knowledge-center/insights/polydispersity-what-does-it-mean-for-dls-and-chromatography. Acesso em: abr. 2025.
[27] MALVERN PANALYTICAL. DLS terms defined. Disponível em: https://www.malvernpanalytical.com/en/learn/knowledge-center/whitepapers/wp111214dlstermsdefined. Acesso em: abr. 2025.
[28] YU, B.; ZHANG, Y.; ZHENG, W.; FAN, C.; CHEN, C. T. Positive surface charge enhances selective cellular uptake and anticancer efficacy of selenium nanoparticles. Inorganic Chemistry, Washington, v. 51, n. 16, p. 8956–8963, 2012. DOI: https://doi.org/10.1021/ic301050v
[29] KREGIEL, D.; BERLOWSKA, J.; SZUBZDA, B. Novel permittivity test for determination of yeast surface charge and flocculation abilities. Journal of Industrial Microbiology & Biotechnology, Dordrecht, v. 39, n. 12, p. 1881–1886, 2012. DOI: https://doi.org/10.1007/s10295-012-1193-y
[30] ACHILLI, E.; SIRI, M.; FLORES, C. Y.; KIKOT, P. A.; FLOR, S.; MARTINEFSKI, M.; LUCANGIOLI, S.; ALONSO, S. del V.; GRASSELLI, M. Radiolysis effect of the high proportion of ethanol in the preparation of albumin nanoparticle. Radiation Physics and Chemistry, Oxford, v. 169, p. 108387, 2020. DOI: https://doi.org/10.1016/j.radphyschem.2020.108775
[31] KOZMÉR, Z.; TAKÁCS, E.; WOJNÁROVITS, L.; ALAPI, T.; HERNÁDI, K.; DOMBI, A. The influence of radical transfer and scavenger materials in various concentrations on the gamma radiolysis of phenol. Radiation Physics and Chemistry, Oxford, v. 124, p. 52–57, 2016. DOI: https://doi.org/10.1016/j.radphyschem.2015.12.011
[32] SUDARE, T.; UENO, T.; WATTHANAPHANIT, A.; SAITO, N. Accelerated nanoparticles synthesis in alcohol-water-mixture-based solution plasma. Physical Chemistry Chemical Physics, Cambridge, v. 17, n. 45, p. 30255–30259, 2015. DOI: https://doi.org/10.1039/C5CP05168A
[33] TONTO, P.; MEKASUWANDUMRONG, O.; PHATANASRI, S.; PAVARAJARN, V.; PRASERTHDAM, P. Preparation of ZnO nanorod by solvothermal reaction of zinc acetate in various alcohols. Ceramics International, Kidlington, v. 34, n. 1, p. 57–62, 2008. DOI: https://doi.org/10.1016/j.ceramint.2006.08.003
[34] THANH, N. T. K.; MACLEAN, N.; MAHIDDINE, S. Mechanisms of nucleation and growth of nanoparticles in solution. Chemical Reviews, Washington, v. 114, p. 7610–7630, 2014. DOI: https://doi.org/10.1021/cr400544s
[35] NIETO, C.; MARCELO, G.; VEGA, M.; MARTÍN DEL VALLE, E. M. Antineoplastic behavior of polydopamine nanoparticles prepared in different water/alcohol media. Colloids and Surfaces B: Biointerfaces, Amsterdam, v. 199, p. 111506, 2021. DOI: https://doi.org/10.1016/j.colsurfb.2020.111506
[36] NAGHAVI, K.; SAION, E.; REZAEE, K.; YUNUS, W. M. M. Influence of dose on particle size of colloidal silver nanoparticles synthesized by gamma radiation. Radiation Physics and Chemistry, Oxford, v. 79, n. 12, p. 1203–1208, 2010. DOI: https://doi.org/10.1016/j.radphyschem.2010.07.009
[37] GEROLIS, L. G. L.; PEREIRA, A. G.; GONÇALVES, L. S.; GASTELOIS, P. L.; NEVES, M. J. Synthesis and characterization of 0D and 1D selenium nanostructures by green chemistry and evaluation of the radioprotective, radiosensitizing and antioxidant properties following exposure to ionizing radiation in vitro. Materials Chemistry and Physics, Lausanne, v. 277, p. 125452, 2022. DOI: https://doi.org/10.1016/j.matchemphys.2021.125452
[38] DISPENZA, C.; GRIMALDI, N.; SABATINO, M. A.; SOROKA, I. L.; JONSSON, M. Radiation-engineered functional nanoparticles in aqueous systems. Journal of Nanoscience and Nanotechnology, Valencia, v. 15, n. 5, p. 3445–3467, 2015. DOI: https://doi.org/10.1166/jnn.2015.9865
[39] ALSHAAL, T.; SZABOLCSY, É. D.; FÁRI, M.; VERES, S.; KASZÁS, L.; KOVÁCS, Z.; EISSA, F.; ELHAWAT, N. Agricultural sustainability and the challenges of selenium nanoparticles (SeNPs): Their role in supporting the environmental economy. Plant Stress, Amsterdam, v. 16, p. 100846, 2025. DOI: https://doi.org/10.1016/j.stress.2025.100846
[40] ŠRÁMEK, M.; PRAUS, L.; BENADA, O.; TLUSTOŠ, P. Selenium nanoparticles: small innovations with mighty impact on crop performance and nutritional quality? Chemical and Biological Technologies in Agriculture, Berlin, v. 13, n. 1, 2026. DOI: https://doi.org/10.1186/s40538-026-00919-x
[41] BARANI, A.; ALIZADEH, S. R.; EBRAHIMZADEH, M. A. A comprehensive review on catalytic activities of green-synthesized selenium nanoparticles on dye removal for wastewater treatment. Water, Basel, v. 15, n. 18, p. 3295, 2023. DOI: https://doi.org/10.3390/w15183295
Descargas
Publicado
Declaración de disponibilidad de datos
Los datos que respaldan los resultados de este estudio están disponibles con el autor de correspondencia previa solicitud razonable. Los conjuntos de datos incluyen las mediciones experimentales obtenidas mediante análisis de DLS, UV–Vis, SEM, TEM, XRD y EDS utilizados en la caracterización de nanopartículas de selenio.
Número
Sección
Licencia
Derechos de autor 2026 Guilherme Henrique Domingos de Franco, Thayna Felizardo dos Santos, Luciana Mara Costa Moreira, Alline Gomes Pereira, Luanai Graziele Luquini Gerolis, Maria Jose Neves

Esta obra está bajo una licencia internacional Creative Commons Atribución 4.0.
Licencia: los artículos de BJRS tienen una licencia internacional Creative Commons Attribution 4.0, que permite el uso, el intercambio, la adaptación, la distribución y la reproducción en cualquier medio o formato, siempre que se otorgue el crédito correspondiente al autor o autores originales y a la fuente, proporcione un enlace a la licencia Creative Commons e indique si se realizaron cambios. Las imágenes u otros materiales de terceros en el artículo están incluidos en la licencia Creative Commons del artículo, a menos que se indique lo contrario en una línea de crédito al material. Si el material no está incluido en la licencia Creative Commons del artículo y su uso previsto no está permitido por la regulación legal o excede el uso permitido, el autor deberá obtener el permiso directamente del titular de los derechos de autor. Para ver una copia de esta licencia, visite http://creativecommons.org/licenses/by/4.0/























