New gold-198 nanoparticle synthesis to be used in cancer treatment
DOI:
https://doi.org/10.15392/bjrs.v9i1A.1260Palabras clave:
Nanoparticles (J01.637.512.600), Brachytherapy (E02.815.150), Radiochemistry (H01.181.529.776)Resumen
Gold nanoparticles (NPs) have been intriguing scientists for over 100 years. Recently, they have been studied for new applications such as cancer treatment. Although the synthesis of gold nanoparticles is extensively reported, in the majority of cases the methodology is confused and/or not clear. We describe a new synthesis methodology for radioactive gold‐198 NPs. Gold-198 was activated in IPEN IEA-01 nuclear reactor. After that, chloroauric acid (HAuCl4) was formed by dissolving the radioactive gold with aqua regia and performing repeated heating cycles. 0.1 mM HAuCl4 containing 100 μL of 1 M NaOH was prepared in a flask equipped with a reflux condenser. The solution was brought to boil and stirred with a PTFE‐coated magnetic stir‐bar. Then 5 mL of sodium citrate was rapidly added. The reaction turns from light yellow to clear, black, dark purple until the solution attained a wine‐red color (2–3 min). Dynamic light scattering (DLS) confirmed 8 nm particles. The presence of gold‐198 (197.968 g/mol; half‐life: 2.69517; decay mode: β‐; average energy: 1.3723 MeV) was confirmed by an ORTEC HPGe detector. DLS was performed after complete decay confirming the 8 nm diameter maintenance. We were able to achieve radioactive gold‐198 NPs and are performing further studies such as: coating reactions, in‐vitro and in‐vivo studies.
Descargas
Referencias
ADAMS, M. Nanoparticles Technology Handbook. New York: NY RESEARCH PRESS, 2015.
DANIEL, M.-C.; ASTRUC, D. Gold Nanoparticles: Assembly, Supramolecular Chemistry, Quantum-Size-Related Properties, and Applications toward Biology, Catalysis, and Nanotechnology. Chemical reviews, v. 104, 1, p. 293-346, 2004.
THE NATIONAL PROGRAMME ON TECHNOLOGY ENHANCED LEARNING (NPTEL); BALAGURU, R.J.B.; JEYAPRAKASH, B.G. Electrical & Electronics Engineering – Semiconductor Nanodevices: Introduction to Materials and Classification of Low Dimensional Materials. Available at: <https://nptel.ac.in/courses/115106076/Module%205/Module%205.pdf>. Last accessed: Mar. 26, 2019.
FARADAY, M. The Bakerian Lecture: Experimental Relations of Gold (and Other Metals) to Light. Philos. Trans. R. Soc. London, v. 147, p. 145-181, 1857.
AMENDOLA, V.; PILOT, R.; FRASCONI, M.; MARAGÒ, O.M.; IATÌ, M.A. Surface plasmon resonance in gold nanoparticles: a review. J. Phys.: Condens. Matter, v. 29, 20, p. 203002, 2017.
KELLY, K.L.; CORONADO, E.; ZHAO, L.L.; SCHATZ, G.C. The Optical Properties of Metal Nanoparticles: The Influence of Size, Shape, and Dielectric Environment. The Journal of Physical Chemistry B, v. 107, 3, p. 668-677, 2003.
PLUCHERY, O.; REMITA, H.; SCHAMING, D. Demonstrative experiments about gold nanoparticles and nanofilms: an introduction to nanoscience. Gold Bulletin, v. 46, 4, p. 319-327, 2013.
CHANDRA, P.; SINGH, J.; SINGH, A.; SRIVASTAVA, A.; GOYAL, R.N.; SHIM, Y.B. Gold Nanoparticles and Nanocomposites in Clinical Diagnostics Using Electrochemical Methods. Journal of Nanoparticles, v. 2013, p. 12, 2013.
CONDE, J.; DORIA, G.; BAPTISTA, P. Noble Metal Nanoparticles Applications in Cancer. Journal of Drug Delivery, v. 2012, p. 751075, 2012.
DARUICH DE SOUZA, C.; RIBEIRO NOGUEIRA, B.; ROSTELATO, M.E.C.M. Review of the methodologies used in the synthesis gold nanoparticles by chemical reduction. J. Alloys Compd., v. 798, p. 714-740, 2019.
RALIYA, R.; SAHA, D.; CHADHA, T.S.; RAMAN, B.; BISWAS, P. Non-invasive aerosol delivery and transport of gold nanoparticles to the brain. Sci. Rep., v. 7, p. 44718-44718, 2017.
LI, W.; ZHAO, X.; DU, B.; LI, X.; LIU, S.; YANG, X.-Y.; DING, H.; YANG, W.; PAN, F.; WU, X.; QIN, L.; PAN, Y. Gold Nanoparticle–Mediated Targeted Delivery of Recombinant Human Endostatin Normalizes Tumour Vasculature and Improves Cancer Therapy. Sci. Rep., v. 6, p. 30619, 2016.
LUCKY, S.S.; SOO, K.C.; ZHANG, Y. Nanoparticles in Photodynamic Therapy. Chem. Rev., v. 115, 4, p. 1990-2042, 2015.
GARCIA CALAVIA, P.; BRUCE, G.; PEREZ-GARCIA, L.; RUSSELL, D.A. Photosensitiser-gold nanoparticle conjugates for photodynamic therapy of cancer. Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology, v. 17, 11, p. 1534-1552, 2018.
ZHANG, Y.; CHU, W.; FOROUSHANI, A.D.; WANG, H.; LI, D.; LIU, J.; BARROW, C.J.; WANG, X.; YANG, W. New Gold Nanostructures for Sensor Applications: A Review. Materials, v. 7, 7, p. 5169-5201, 2014.
MA, J.; LIU, Y.; GAO, P.F.; ZOU, H.Y.; HUANG, C.Z. Precision improvement in dark-field microscopy imaging by using gold nanoparticles as an internal reference: a combined theoretical and experimental study. Nanoscale, v. 8, 16, p. 8729-8736, 2016.
WONG, A.C.; WRIGHT, D.W.; CONRAD, J.A., Functionalized Gold Nanoparticles for Detection of Cancer Biomarkers, In: General Methods in Biomarker Research and their Applications. Dordrecht: Springer Netherlands, 2014.
CHANDA, N.; KAN, P.; WATKINSON, L.D.; SHUKLA, R.; ZAMBRE, A.; CARMACK, T.L.; ENGELBRECHT, H.; LEVER, J.R.; KATTI, K.; FENT, G.M.; CASTEEL, S.W.; SMITH, C.J.; MILLER, W.H.; JURISSON, S.; BOOTE, E.; ROBERTSON, J.D.; CUTLER, C.; DOBROVOLSKAIA, M.; KANNAN, R.; KATTI, K.V. Radioactive gold nanoparticles in cancer therapy: therapeutic efficacy studies of GA-198AuNP nanoconstruct in prostate tumor–bearing mice. Nanomed. Nanotechnol. Biol. Med., v. 6, 2, p. 201-209, 2010.
AMERICAN CANCER SOCIETY. Global Cancer Facts & Figures. (Atlanta, USA: 2015.
STEWART, B.; WILD, C. World Cancer Report 2014. International Agency for Research on Cancer, 2014.
MINISTÉRIO DA SAÚDE. INSTITUTO NACIONAL DE CÂNCER. Incidência de Câncer no Brasil. Available at: <https://www.inca.gov.br/sites/ufu.sti.inca.local/files/media/document/estimativa-2020-incidencia-de-cancer-no-brasil.pdf>. Last accessed: 11 nov., 2019.
ROSTELATO, E.C.M.; DARUICH DE SOUZA, C.; GONZALEZ, A.D.C.C.; NOGUEIRA, B.R.; ZEITUNI, C.A.; FORTIN, M.A.; CHEVALLIER, P. Nanobrachytherapy and its challenges. In: PANNNANO- 1ST PAN AMERICAN CONGRESS OF NANOTECHNOLOGY, 2017, Guarujá- Brasil. Proceedings.
CHOPPIN, G.; LILJENZIN, J.-O.; RYDBERG, J.; EKBERG, C., Chapter 17 - Production of Radionuclides, In: Radiochemistry and Nuclear Chemistry (Fourth Edition). Oxford: Academic Press, 2013.
POLTE, J. Fundamental growth principles of colloidal metal nanoparticles - a new perspective. CrystEngComm, v. 17, 36, p. 6809-6830, 2015.
Descargas
Publicado
Número
Sección
Licencia
Derechos de autor 2021 Brazilian Journal of Radiation Sciences (BJRS)
Esta obra está bajo una licencia internacional Creative Commons Atribución 4.0.
Licencia: los artículos de BJRS tienen una licencia internacional Creative Commons Attribution 4.0, que permite el uso, el intercambio, la adaptación, la distribución y la reproducción en cualquier medio o formato, siempre que se otorgue el crédito correspondiente al autor o autores originales y a la fuente, proporcione un enlace a la licencia Creative Commons e indique si se realizaron cambios. Las imágenes u otros materiales de terceros en el artículo están incluidos en la licencia Creative Commons del artículo, a menos que se indique lo contrario en una línea de crédito al material. Si el material no está incluido en la licencia Creative Commons del artículo y su uso previsto no está permitido por la regulación legal o excede el uso permitido, el autor deberá obtener el permiso directamente del titular de los derechos de autor. Para ver una copia de esta licencia, visite http://creativecommons.org/licenses/by/4.0/
