Primary standardization of Radionuclide 123I

Regio dos Santos Gomes; Carlos José Da Silva; José Ubiratan Delgado; Monica Aguiar Leobino da Silva; R.L. da Silva; Johnny de Almeida Rangel; Luis Alberto Pereira Dias; Alfredo Lopes Ferreira Filho; Octavio L. Trindade Filho

doi:10.15392/2319-0612.2025.2969

Autores/as

Regio dos Santos Gomes LMNRI/IRD/CNEN , Laboratório Nacional de Metrologia das Radiações Ionizantes (LNMRI/IRD/CNEN), https://orcid.org/0000-0003-1282-2629 (no autenticado)
Carlos José Da Silva LMNRI/IRD/CNEN , Laboratório Nacional de Metrologia das Radiações Ionizantes (LNMRI/IRD/CNEN)
José Ubiratan Delgado LMNRI/IRD/CNEN , Laboratório Nacional de Metrologia das Radiações Ionizantes (LNMRI/IRD/CNEN)
Monica Aguiar Leobino da Silva LMNRI/IRD/CNEN , Laboratório Nacional de Metrologia das Radiações Ionizantes
R.L. da Silva LMNRI/IRD/CNEN , Laboratório Nacional de Metrologia das Radiações Ionizantes (LNMRI/IRD/CNEN)
Johnny de Almeida Rangel LMNRI/IRD/CNEN , Laboratório Nacional de Metrologia das Radiações Ionizantes
Luis Alberto Pereira Dias IPEN/CNEN , Instituto de Pesquisas Energéticas e Nucleares
Alfredo Lopes Ferreira Filho LMNRI/IRD/CNEN , Laboratório Nacional de Metrologia das Radiações Ionizantes
Octavio L. Trindade Filho LMNRI/IRD/CNEN , Laboratório Nacional de Metrologia das Radiações Ionizantes (LNMRI/IRD/CNEN)

DOI:

https://doi.org/10.15392/2319-0612.2025.2969

Palabras clave:

Nuclear Medicine, Radiopharmaceuticals, Primary Standardization, Iodine

Resumen

Short half-life radionuclides are essential for Nuclear Medicine. These radionuclides are usually linked to a more complex molecular or cellular structure with pharmacological characteristics. This set is called “radiopharmaceutical” and have been applied for the diagnosis and therapy of diseases. The use of radiopharmaceuticals involves exposure to ionizing radiation, which, although carefully controlled, poses potential health risks to patients and healthcare professionals. To minimize these risks and maintain the benefits of its use, the radiopharmaceutical dose must be administered to patients with high accuracy and precision, this places on National Metrology Institutes new requirements for improvement for primary standardization of these short half-life radionuclides, so that the standards used to calibrate the activity meters in hospitals and nuclear medicine clinics have the greatest possible precision. Iodine-123 is currently used for several applications in radiodiagnosis, the main being in pathologies and tumors in the thyroid. In this work is presented the primary standardization of ¹²³I performed by 4παβ(LS)-γ(NaI(Tl)) live timed anticoincidence counting and no significant radionuclidic impurities have been detected by high resolution gamma ray spectrometry. With this work, LMNRI/IRD prepared for the key comparison of the BIPM K4 series using the SIRTI instrument.

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Biografía del autor/a

Regio dos Santos Gomes, LMNRI/IRD/CNEN, Laboratório Nacional de Metrologia das Radiações Ionizantes (LNMRI/IRD/CNEN),

Born in the city of Duque de Caxias in the state of Rio de Janeiro, he is a federal public servant at CNEN - National Nuclear Energy Commission (CNEN), assigned to IRD - Institute of Radioprotection and Dosimetry, working as Head of Service of the Division of Metrology of Ionizing Radiation designated by INMETRO, as National Laboratory of Metrology of Ionizing Radiation (LNMRI / IRD / CNEN). Coordinates scientific projects with BIPM and LNHB, both from France, Coordinates the PNI - National Program for Intercomparison of Activity Measurements in Environmental Samples. Secretary of Scientific Publication of the Brazilian Society for Radiological Protection (SBPR), being responsible for the journal BJRS - Brazilian Journal of Radiation Science, which we managed, in 2024, to include in the SCIELO collection. Doctoral and Master's student in Radioprotection and Dosimetry of the postgraduate course at IRD / CNEN in the area of Metrology of Ionizing Radiation. Bachelor of Physics from the Federal University of Rio de Janeiro (UFRJ) with experience in the Nuclear area. Systems and support analyst trained, through mentoring, by the Training Manager of IBM/Brazil. He has been a physics and mathematics teacher since 1991 in universities, schools and preparatory courses for public exams, has 15 years of experience in the nuclear area working with open radioactive sources for use in research, medical and industrial applications, photon spectrometry using high-purity germanium detectors (HPGe), Absolute Radionuclide Standardization systems TDCR (Triple-to-Double Coincidence Ratio) developed at LNMRI/IRD/CNEN and the commercial HIDEX SL 300. Has training in Nuclear and Radiation Emergency Response by the Emergency Division of IRD/CNEN. He has over 30 years of experience in Information Technology in developing Commercial, Industrial, Automation and Web systems in several programming languages such as LabVIEW, Python, C++, PHP, JavaSript, HTML, CSS, Visual Basic, Fortran, Pascal, Clipper and Delphi. Databases: Oracle, MySQL, PostgreSQL, Firebird, Access and Dbase. Experience and work with ABNT ISO/IEC 17025, 17043 standards. He is support Vasco da Gama.

Referencias

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