Analysis of the swelling kinetic in hydrogels gelled by radiation and by thermal cycling
DOI:
https://doi.org/10.15392/bjrs.v9i1A.1348Palavras-chave:
hydrogel, radiation, thermal cycling, swelling, crosslinkingResumo
Hydrogels are cross-linked polymer networks, which are of interest in biomedical applications such as drug delivery system. To achieve successful results in this kind of application it is essential to understand the diffusion mechanisms which are generated in the hydrogel during the swelling process. For this reason, this work consists in carrying out an analysis of the swelling kinetics in hydrogels elaborated through gamma radiation and the combination of gamma radiation with thermal cycling processes. The hydrogels were synthesized using biocompatible polymers irradiating their solution at different doses. A swelling test was performed and the diffusion coefficient and the diffusional exponent were calculated, making an analysis of the kind of diffusion mechanism in the hydrogel matrix. This test showed that the higher radiation absorbed used to get the gels, the lower the swelling percentage, as well as the diffusion coefficient of the water molecules in the hydrogel. The results of the kinetic analysis showed an anomalous diffusion mechanism for the gels obtained at 25 kGy. For those gels of 30 kGy, the diffusion was Fickian. Finally since those gels of 35 kGy was not possible to classify it according to the Fick's law of diffusion. Furthermore, we could observe that the hydrogels that had been obtained by thermal cycling and by irradiation had higher swelling percentages compared to those that were only cross-linked by irradiation. This analysis allowed us to understand the intrinsic behavior of the polymer / solvent mesh system at different doses and under two different crosslinking conditions.
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Referências
HOFFMAN, A. Hydrogels for biomedical applications. Advanced drug delivery reviews, 64, 18-23. (2012).
ANSETH, K.; BOWMAN, C.; BRANNON-PEPPAS, L. Mechanical properties of hydrogels and their experimental determination. Biomaterials, 17(17), 1647-1657. (1996).
ROSIAK, J.; JANIK, I.; KADLUBOWSKI, S.; KOZICKI, M.; KUJAWA, P.; STASICA, P.; ULANSKI, P. Radiation formation of hydrogels for biomedical application. Radiation synthesis and modification of polymers for biomedical applications, 5-47. IAEA-TECDOC-1324. (2002)
ECHEVERRI, C.; VALLEJO, C.; LONDOÑO, M. Síntesis y caracterización de hidrogeles de alcohol poli vinílico por la técnica de congelamiento/descongelamiento para aplicaciones médicas. Revista EIA, (12) (2009).
CRESCENZI, V.; CORNELIO, L.; DI MEO, C.; NARDECCHIA, S.; LAMANNA, R. Novel hydrogels via click chemistry: Synthesis and potential biomedical applications. Biomacromolecules, 8(6), 1844-1850(2007).
VASHIST, S.; VASHIST, A.; GUPTA, Y.; AHMAD, S. Recent advances in hydrogel based drug delivery systems for the human body. Journal of Materials Chemistry B, 2(2), 147-166. (2014).
ROSIAK, J.; ULAŃSKI, P. Synthesis of hydrogels by irradiation of polymers in aqueous solution. Radiation Physics and Chemistry, 55(2), 139-151 (1999).
PEPPAS, N.; KORSMEYER, R. Dynamically swelling hydrogels in controlled release applications. Hydrogels in medicine and pharmacy, 3, 109-136. (1987).
SÁEZ, V.; HERNÁEZ, E.; SANZ, A. Mecanismos de liberación de fármacos desde materiales polímeros. Revista Iberoamericana de Polímeros, 5(1), 55-70.6. Hydrogels in drug delivery. Process and challenges. (2004).
RITGER, P.; PEPPAS, N. A simple equation for description of solute release I. Fickian and non-fickian release from non-swellable devices in the form of slabs, spheres, cylinders or discs. Journal of controlled release, 5(1), 23-36. (1987).
SINGH, B.; CHAUHAN N.; KUMAR, S. Radiation crosslinked psyllium and polyacrylic acid based hydrogels for use in colon specific drug delivery. Carbohydrate polymers, 73(3), 446-455. (2008).
BENÍTEZ, J.; LÁREZ VELÁSQUEZ C.; ROJAS DE GÁSCUE, B. Cinética de absorción y transporte del agua en hidrogeles sintetizados a partir de acrilamida y anhídrido maleico. Revista Latinoamericana de Metalurgia y Materiales, 35(2), 242-253. (2015).
RITGER P.; PEPPAS, N. A simple equation for description of solute release II. Fickian and anomalous release from swellable devices. Journal of controlled release, 5(1), 37-42. (1987).
NHO, Y.; LIM, Y.; GWON, H.; CHOI, E. Preparation and characterization of PVA/PVP/glycerin/antibacterial agent hydrogels using γ-irradiation followed by freeze-thawing”. Korean journal of chemical engineering, 26(6), 1675-1678. (2009).
BRANDL, F.; KASTNER, F.; GSCHWIND, R.; BLUNK, T.; TEßMAR, J.; GÖPFERICH, A. Hydrogel-based drug delivery systems: Comparison of drug diffusivity and release kinetics. Journal of Controlled Release, 142(2), 221-228. (2010).
PEPPAS N. Hydrogels and drug delivery. Current opinion in colloid and interface science, 2(5), 531-537. (1997).
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