Experimental hypofractionated IMRT breast dosimetry in a thorax phantom
DOI:
https://doi.org/10.15392/bjrs.v7i2A.722Keywords:
radiotherapy, breast cancer, dosimetry, IMRTAbstract
The present research proposal aimed to measure absorbed dose in a thorax phantom with synthetic breasts provided by an Intensity-Modulate Radiation Therapy (IMRT) protocol in an arbitrary RT center. As methods, a thorax simulator was prepared by the Ionizing Radiation Research Group (NRI) and radiochromic films were used for dose measurements. Tomographic images were taken at NRI phantom. Expositions were procedure in the Elektra 6MV LINAC. Hypofractionated regime was considered with a dose fraction of 2,7Gy in 16 fractions at the prescribed dose of 43.2 Gy at 95% of PTV. The dose comparison from the treatment planning system (TPS), Xio (Elekta) and from the experimental data was performed. The internal two-dimensional dose maps in the breast, at the skin on the left and contra-lateral breasts, heart and lungs. The measurements showed that the internal mean doses taken at the synthetic breast presented mean dose above the prescribed dose. Moreover, in general, doses to organs at risk (OARs) were within the Memorial Sloan Kettering Cancer Center (MSKCC) criteria. The non-full reproduction of the build-up region in the films had occurred due to the assymetrical positioning of the films in the inner breast, in the addition to their non-constant distance from the skin. Hot regions were present, may be due to the beam angulation chosen and the increase of MUs in the IMRT plane. As conclusions, the films can supply details and information that TPS does not provide. Assertiveness in clinical IMRT protocols can improve the prognosis and effectiveness of breast cancer treatment bring-ing possible clinical benefits.
Downloads
References
Thwaites D 2013 J. Phys.: Conf. Ser. 444 012006.
Wolfsberger LD, Wagar M, Nitsh P, Bhagwat MS, Zygmanski P (2010) “An-gular dose dependency of MatriXX TM and its calibration”. J Appl Clin Med Phys 11(1):241-251[2]
Devic S, Aldelaijan S, Mohammed H, Tomic N, Liang LH, DeBlois F, Seuntjens J.”Absorption spectra time evolution of EBT-2 model GAF-CHROMIC film”. Med Phys. 2010 May;37(5):2207-
Aland T, Kairn T, Kenny J (2011) Evaluation of a Gafchromic EBT2 film dosimetry system for radiotherapy quality assurance. Australas Phys Eng Sci Med 34(2):251-260
Kairn T, Hardcastle N, Kenny J et al. (2011) “EBT2 radiochromic film for quality assurance of complex IMRT treatments of the prostate: micro-collimated IMRT, RapidArc, and TomoTherapy”Australas Phys Eng Sci 34(3):333-343
Butson MJ, Yu PKN, Cheung T, Metcalfeb P. (2003). “Radiochromic film for medical radiation dosimetry” Mater Sci Eng: R Rep 2003, 41(3-5):61-120
ISP - International Specialty Products. Gafchromic EBT2 -Self-Developing Film for Radiotherapy Dosimetry. New Jersey: ISP, 2010
Huet, C., Dagois, S., Derreumemaux, S., Trompier, F., Chenaf, C., Robbes, I., (2012). “Characterization and optimization of EBT2 radiochromic films dosimetry system for precise measurements of output factors in small fields used in radiotherapy”. Radiat. Meas. 47, 40-49.
McCullough e Holmes, Med. Phys., 12: 237-242, 1985.
ISP - International Specialty Products. Gafchromic Self-Developing Dosimetry Films (EBT2, EBT3, Cyberknife, HD-V2, MD-V3, RTQA2) Ashland Inc - ISP
Siebel, Osmar Franca. “Desenvolvimento de um dosímetro in vivo a MOSFET para aplicações em radioterapia”, Tese de Doutorado, Universidade Federal de Santa Catarina, 2013.
Nogueira, Luciana Batista. “Síntese, caracterização e dosimetria de sementes radioativas de Ho e HoZr para tratamento de cancer de mama”. 2012. Tese de Doutorado, Universidade Federal de Minas Gerais, Belo Horizonte; 2012
Nogueira, Luciana Batista; Silva, Hugo Leonardo Lemos; Campos, Tarcísio Passos Ribeiro. Experimental dosimetry in conformal breast teletherapy com-pared with the planning system. Applied Radiation and Isotopes , v. 97, p. 93-100, 2015
Schettini, Mônica Paiva; Maia, Margareth e Campos, Tarcisio P. Ribeiro. The development of an anthropomorphic and anthropometric thorax female phantom for experimental radiodosimentry. International Journal of Low Radiation, v. 4, p. 124-135, 2007.
Campos, T.P.R. Thompson, L. Nogueira, L.B. Duarte, I.L. Matos, C.H. Teixeira, A.S. Maia, M. Schettini,M.P. Toledo, J.M. inventors, Anthropomorphic and anthropometric simulators of the structures, tissues, and organs of the human body, Brazil patent BR. 2012. (PI1004465-004465).
ICRU 44 - Tissue substitutes in radiation dosimetry and measurement. In: international commission on radiation units and measurements report 44, ICRU, Bethesda, MD (1989)
Hande Bas Ayata∗, Metin Güden, Cemile Ceylan, Nadir Kücük, Kayihan Engin “Comparison of dose distributions and organs at risk (OAR) doses in conventional tangential technique (CTT) and IMRT plans with different numbers of beam in left-sided breast cancer” Department of Radiation Oncology, Anadolu Medical Center, Gebze, Kocaeli, Turkey
Maria Tolia, Kalliopi Platoni, [...], and Vassilis Kouloulias Assessment of contralateral mammary gland dose in the treatment of breast cancer using accelerated hypofractionated radiotherapy
Podgorsak, E.B. Podgorsak, E.B. (Ed.). (2005). External photon beams: Physical aspects. International Atomic Energy Agency (IAEA): IAEA.
Devic S, Tomic N, Lewis D. Reference radiochromic film dosimetry: review of technical aspects”. Phys Med 2016; 32: 541–56.
Lee, N., Riaz, N., Lu, J. Target Volume Delineation for Conformal and Intensity-Modulated Radiation Therapy. in: L. Brady, S. Combs, J. Lu (Eds.) Medical Radiology: Radiation Oncology. Springer, New York; 2015.
Popescu CC, Olivotto I, Patenaude VV, et al. “Inverse-planned, dynamic, multi-beam, intensity-modulated radiation therapy (IMRT): a promising technique when target volume is the left breast and internal mammary lymph nodes”. Med Dosim 2006;31:283–91.
Sajad A. Rather, M. Mohib-ul Haq, Nazir A. Khan, Ajaz A. Khan, A.G. Sofi, Determining the contralateral breast dose during radiotherapy of breast cancer using rainbow dosimeter. In Journal of Radiation Research and Applied Sciences, Vol 7, Issue 4, 2014, pp 384-389
Soleymanifard, Shokouhozaman et al. In Vivo Skin Dose Measurement in Breast Conformal Radiotherapy. Contemporary Oncology 20.2 (2016): 137–140. PMC. Web. 29 Sept. 2017.
Al-Rahbi, Zakiya Salem et al. Dosimetric Comparison of Intensity Modulated Radiotherapy Isocentric Field Plans and Field in Field (FIF) Forward Plans in the Treatment of Breast Cancer. Journal of Medical Physics / Association of Medical Physicists of India 38.1 (2013): 22–29. PMC. Web. 29 Sept. 2017.
Han, Eun Young et al. Estimation of the Risk of Secondary Malignancy Aris-ing from Whole-Breast Irradiation: Comparison of Five Radiotherapy Modalities, Including TomoHDA. Oncotarget 7.16 (2016): 22960–22969. PMC. Web. 29 Sept. 2017.
Published
Issue
Section
Categories
License
Copyright (c) 2021 Brazilian Journal of Radiation Sciences
This work is licensed under a Creative Commons Attribution 4.0 International License.
Licensing: The BJRS articles are licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
How to Cite
