Performance based on NEMA NU-4 2008 Standard of CDTN/CNEN’s Small Animal PET Scanner
DOI:
https://doi.org/10.15392/bjrs.v10i3.2006Keywords:
quality control, NEMA NU 4-2008, Preclinical PETAbstract
This study aimed to evaluate the general performance of the preclinical PET scanner (LabPET Solo 4, GE) at CDTN/CNEN using the NEMA NU 4-2008 protocol. The performance parameters include: (i) spatial resolution; (ii) scatter fraction and counts rate performance; (iii) sensitivity and (iv) image quality. For the evaluation specific simulators and a sealed radioactive source of Sodium-22 were used. The results revealed that the NEMA-based radial spatial resolution ranged from 1.79 mm at the center of the FOV to 2.49 mm at a radial offset of 25mm. Tangential resolution ranged from 1.95mm at the center of the FOV to 3.50mm at a radial offset of 25mm. Axial resolution ranged from 1.78mm at the center of the FOV to 5.42mm at a radial offset of 25mm. Iterative image reconstruction improved the radial spatial resolution to 0.93mm at the center of the FOV. For the mouse-sized phantom, the peak noise equivalent count rate (NECR) was 37.8kcps at 85MBq whereas the peak true count rate was 169.9kcps at 125MBq with a count loss of 7.8% for the maximum rate reached at 103.3MBq. The peak of sensitivity (S) and absolute sensitivity (SA) at the center of axial field-of-view (FOV) is 5.7cps.Bq-1 and 0.63%, respectively. The overall imaging capabilities of the scanner were assessed using the NEMA image-quality phantom. The image roughness was 9.5%. Spillover rates (SORs) in air and in water were 0.26 and 0.17 respectively. The recovery coefficients (RCs) were 0.12 for the 1-mm-diameter rod and 0.91 for the 5-mm-diameter rod. The results demonstrate that CDTN/CNENsmall animal PET scanner has adequate reliability and acquired images are compatible with international quality standards for the molecular imaging research.
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References
YAO R.; LECOMTE R.; CRAWFORD E. Small-Animal PET: What is it, and why do we need it? Journal of Nuclear Medicine Technology. Vol. 40 nº3, pp.157-165. 2012. DOI: https://doi.org/10.2967/jnmt.111.098632
GONTIJO, R. M. G. Proposta de Programa de Garantia da Qualidade para Imagem Mole-cular Pré-Clínica. 2019. 275 f. Doctoral Thesis (Doutorado em Ciência e Tecnologia das Radi-ações, Minerais e Materiais) – Centro de Desenvolvimento da Tecnologia Nuclear, Comissão Nacional de Energia Nuclear, Belo Horizonte, In Portuguese, 2019.
NEMA - National Electrical Manufacturers Association. Performance Measurements of Small Animal Positron Emission Tomographs. Rosslyn VA; 2008 Standards Publication NU 4-2008.
GONTIJO, R. M. G., FERREIRA, A. V., SILVA, J. B., MAMEDE, M. Quality control of small animal PET scanner: The Brazilian Scenario. Brazilian Journal of Radiation Sciences. vol. 08 (2). pp. 1-09. 2020.
GE Healthcare Technologies, 2011. Triumph Service Guide Technical Publication. Revision Draft 6, Copyright. Available in: <http://www.gehealthcare.com> 2011.
TETRAULT, M.A. et al., 2008. System Architecture of the LabPET Small Animal PET Scanner. IEEE Transactions on Nuclear Science. 55(5), 2546-2550. DOI: https://doi.org/10.1109/TNS.2008.2002326
FONTAINE, R. et al. 2009. The hardware and signal processing architecture of LabPETTM, a small animal APD-based digital PET scanner. IEEE Transactions on Nuclear Science. 56, 3-9. DOI: https://doi.org/10.1109/TNS.2008.2007485
GONTIJO, R. M. G., FERREIRA, A. V., SILVA, J. B., MAMEDE, M. Image quality assess-ment using NEMA NU 4/2008 standards in small animal PET scanner. Brazilian Journal of Radiation Sciences. 07 (2A). pp. 1-13. 2019.
Bergeron, M. et al. Imaging performance of LabPET APD-based digital PET scanners for pre-clinical research. Physics in medicine and Biology. 59, 661-678. 2014. DOI: https://doi.org/10.1088/0031-9155/59/3/661
Prasad, R., Ratib, O., Zaid, H. NEMA NU-04-based Performance Characteristics of the LabPET-8TM Small Animal PET Scanner. Physics in Medicine and Biology. 56(20), 6649-6664. 2011. DOI: https://doi.org/10.1088/0031-9155/56/20/009
Bergeron, M. et al. Performance Evaluation of the LabPET APD-Based Digital PET Scan-ner. IEEE Transactions on Nuclear Science. 56(1). 2009. DOI: https://doi.org/10.1109/TNS.2008.2010257
Gontijo, R.M.G., Ferreira, A.V., Souza, G.C.A., Mendes, B.M., Silva, J.B., Mamede, M. 2020. Image quality evaluation of a small animal PET scanner. Brazilian Journal of Radiation Sciences. 8(1), 01-13. 2020. DOI: https://doi.org/10.15392/bjrs.v8i1.1155
IAEA - International Atomic Energy Agency (IAEA). Quality Control Guidance for Nu-clear Medicine Equipment. Guidelines of Radiation and Nuclear Safety Authority – STUK, 2010.
GONTIJO, R. M. G., FERREIRA, A. V., SOUZA, G. C. A., BARBOSA, J. V. C., MAMEDE, M. Current Brazilian Scenario about Quality Assurance in preclinical PET imaging systems. 2021 International Nuclear Atlantic Conference – INAC 2021 Virtual meeting, Brazil, November 29 – December 2, 2021.
OSBORNE, D. R., KUNTNER, C., BERR, S., STOUT, D. Guidance for Efficient Small Animal Imaging Quality Control. Molecular Imaging and Biology. 19 pp. 485-498. 2016. DOI: https://doi.org/10.1007/s11307-016-1012-3
Gontijo, R.M.G., Ferreira, A. V., Silva, J. B., Mamede, M. Image quality assessment using NEMA NU 4/2008 standards in small animal PET scanner. Brazilian Journal of Radiation Sciences. 7(2A), 01-12. 2019. DOI: https://doi.org/10.15392/bjrs.v7i2A.580
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